GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12748152 | 1 | rs11807824 | chr1:27270338 | GPATCH3 | chr1:27216980-27226962:- | 0.2 | 3.94 | 8.6E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs6537837 | 1 | rs11810577 | chr1:110138109 | AMIGO1 | chr1:110049447-110052336:- | 0.18 | 4.81 | 1.76E-6 | Major depressive disorder |
| BRCA | cis | rs2275426 | 1 | rs11810993 | chr1:46478793 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.77 | 3.8E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11810993 | chr1:46478793 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.47 | 0.000535 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11810993 | chr1:46478793 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.86 | 1.33E-6 | Body mass index |
| BRCA | cis | rs2066819 | 1 | rs118130855 | chr12:56677979 | COQ10A | chr12:56660642-56664748:+ | -0.29 | -4 | 6.83E-5 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs118130855 | chr12:56677979 | RPS26 | chr12:56435686-56438005:+ | -0.3 | -3.86 | 0.000119 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs118130855 | chr12:56677979 | SLC39A5 | chr12:56623820-56631627:+ | -0.26 | -3.78 | 0.000166 | Psoriasis vulgaris |
| BRCA | cis | rs1853207 | 1 | rs118161033 | chr10:96389223 | C10orf129 | chr10:96953957-96988685:+ | 0.26 | 4.72 | 2.71E-6 | Blood metabolite levels |
| BRCA | cis | rs11190604 | 1 | rs11816840 | chr10:102309220 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.58 | 6.01E-25 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11825685 | 1 | rs11825685 | chr11:134573810 | THYN1 | chr11:134118175-134123260:- | -0.17 | -3.59 | 0.000349 | IgG glycosylation |
| BRCA | cis | rs2507838 | 1 | rs11826771 | chr11:58508972 | OSBP | chr11:59341871-59383617:- | 0.24 | 3.67 | 0.000253 | Body mass (lean) |
| BRCA | cis | rs2507838 | 1 | rs11826771 | chr11:58508972 | ZFP91 | chr11:58346587-58388513:+ | 0.23 | 4.31 | 1.76E-5 | Body mass (lean) |
| BRCA | cis | rs1568889 | 1 | rs11826837 | chr11:28322566 | METT5D1 | chr11:28129798-28355054:+ | 0.14 | 4.06 | 5.32E-5 | Bipolar disorder |
| BRCA | cis | rs11830157 | 1 | rs11830157 | chr12:118265441 | FBXW8 | chr12:117348761-117470180:+ | 0.14 | 4.02 | 6.17E-5 | Coronary artery disease |